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Regorafenib induces DNA damage and enhances PARP inhibitor efficacy in pancreatic ductal carcinoma

Regorafenib induces DNA damage and enhances PARP inhibitor efficacy in pancreatic ductal carcinoma

June 19, 2025 Category: Blog

Abstract Background There is increasing interest in enhancing the response of the PARP inhibitor olaparib, which is currently approved for pancreatic ductal adenocarcinoma (PDAC) patients with defects in DNA damage repair associated with germline BRCA1/2 mutations.Moreover, agents that can mimic these defects in the absence of germline BRCA1/2 muta

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Detection and Grading Method of Pomelo Shape Based on Contour Coordinate Transformation and Fitting

June 19, 2025 Category: Blog

Automatic grading method of pomelo fruit according to the shape and size is urgently needed in the industry since the work mainly depends on artificial judgment currently.In this research, a method, which detected the vertical and horizontal size of pomelo by using contour coordinate transformation fitting, fruit shape feature extraction and direct

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EVALUATION OF X-RAY RADIATION SHIELDING OF CONCRETE WITH TWO POLYMERIC ADDITIVES

June 19, 2025 Category: Blog

The safety factor is the most important point to consider when using medical radiology, as the walls of X-ray rooms must be immune to the radiation at a safe level.The theinsulationsthat are currently used in large rooms in the radiation is a lead substance and because of this substance of toxic effects on the human was only touch or Pediatric Uppe

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